Ethyl Triphenyl Phosphonium Iodide

Ethyl Triphenyl Phosphonium Iodide

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Ethyl triphenyl phosphonium iodide (ETI) is a quaternary ammonium salt with the chemical formula (C6H5)3PCH2CH3I. It is a white or off-white crystalline solid that is soluble in organic solvents like ethanol, acetone, and dichloromethane. ETI is commonly used as a Wittig reagent in organic synthesis.

In organic synthesis, ETI is used as a Wittig reagent to convert carbonyl compounds, such as aldehydes and ketones, into alkenes. The reaction between ETI and the carbonyl compound results in the formation of a ylide intermediate, which then reacts with an electrophilic reagent to produce an alkene. This reaction is useful in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals.

ETI is generally considered safe to handle and use, but it can be an irritant if it comes into contact with skin or eyes. Protective equipment like gloves and safety glasses should be worn when handling ETI. Additionally, it should be stored in a cool, dry place away from sources of heat and flame.


1. Ethyl triphenyl phosphonium iodide is what?

Ans - C18H21PI is the chemical formula for the organic compound ethyl triphenyl phosphonium iodide. It is an organic solvent-soluble white solid.

2. How is ethyl triphenyl phosphonium iodide structured?

Ans - The chemical formula for ethyl triphenyl phosphonium iodide is C18H21PI. It is made composed of three phenyl rings, with the outer rings connected to an ethyl group and an iodide ion, respectively, and the central ring attached to a phosphonium ion.

3. How is ethyl triphenylphosphonium iodide used?

Ans - The principal application of ethyl triphenyl phosphonium iodide is as a coupling reagent in chemical synthesis. Additionally, it serves as a catalyst in the polycondensation of dicarboxylic acids as well as the manufacture of esters, amides, and other compounds.

4. How should ethyl triphenyl phosphonium iodide be handled safely?

Ans - It is important to take the right safety precautions when handling ethyl triphenyl phosphonium iodide. It needs to be stored in a cool, dry area away from heat, sparks, and open fires. The substance must not be swallowed, breathed, or come into contact with the skin or eyes.

5. What is the procedure for making ethyl triphenyl phosphonium iodide?

Ans - A reaction between triphenylphosphine and ethyl iodide produces ethyl triphenyl phosphonium iodide. Normally, a basic like sodium hydroxide or potassium hydroxide is present during this reaction.